منابع مشابه
2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular-Cellular Mechanisms in the Progression of Atherosclerosis.
Atherosclerosis is initiated by the subendothelial accumulation of apoB-lipoproteins, which initiates a sterile inflammatory response dominated by monocyte-macrophages but including all classes of innate and adaptive immune cells. These inflammatory cells, together with proliferating smooth muscle cells and extracellular matrix, promote the formation of subendothelial lesions or plaques. In the...
متن کامل2015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis.
Atherosclerosis is an inflammatory disease of the arterial wall. It is accompanied by an autoimmune response against apolipoprotein B-100, the core protein of low-density lipoprotein, which manifests as CD4 T cell and antibody responses. To assess the role of the autoimmune response in atherosclerosis, the nature of the CD4 T cell response against apolipoprotein B-100 was studied with and witho...
متن کاملRussell Ross Memorial Lecture in Vascular Biology Cellular and Molecular Mechanisms of Diabetes Mellitus – Accelerated Atherosclerosis
I am honored to deliver the 2013 Russell Ross Memorial Lecture in Vascular Biology. Russell Ross (1929–1999) was Professor of Pathology and served as Chair of the Pathology Department and Associate Dean of Scientific Affairs at the University of Washington School of Medicine. His scientific career was marked by several seminal discoveries. His early research interests focused on the processes o...
متن کامل2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis.
Adults with diabetes mellitus are much more likely to have cardiovascular disease than those without diabetes mellitus. Genetically engineered mouse models have started to provide important insight into the mechanisms whereby diabetes mellitus promotes atherosclerosis. Such models have demonstrated that diabetes mellitus promotes formation of atherosclerotic lesions, progression of lesions into...
متن کاملRussell Ross Memorial Lecture in Vascular Biology Cellular and Molecular Mechanisms of Diabetes Mellitus – Accelerated Atherosclerosis Karin
I am honored to deliver the 2013 Russell Ross Memorial Lecture in Vascular Biology. Russell Ross (1929–1999) was Professor of Pathology and served as Chair of the Pathology Department and Associate Dean of Scientific Affairs at the University of Washington School of Medicine. His scientific career was marked by several seminal discoveries. His early research interests focused on the processes o...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1999
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65382-5